The aim of the present study was to compare sensory and motor function in female runners with and without Medial Tibial Stress Syndrome (MTSS). The present study was descriptive and comparative. Fifty female endurance runners with an age range of 20 to 30 years were divided in two groups MTSS and without injuries. Yates criterion was used to diagnose the injured group and to assess sensory function and motor function we used ankle and knee joint position sense and Functional Movement Screening(FMS) test respectively. The results showed significant difference between the two groups in the subscales and the overall score of the FMS test as well as knee and ankle joint position sense (P <0.05) and individuals in the group with MTSS had more deviation in the reproduction of the target angle. Therefore, it is recommended that endurance runners with MTSS pay attention to their weaknesses in their exercise program.