Training loads are important for improving performance and injury prevention. So the present study aimed to monitor training loads and investigate the prediction of non-contact injuries by parameters related to internal and external loads in a Premier League team during a season. 23 players of the Foulad Mobarakeh Sepahan soccer team participated in the study. The training load was measured using GPS and Borg’s questionnaire. The parameters of acute load, chronic load, internal load, acute to chronic load ratio, monotony, strain, and the number of non-contact injuries were calculated. Spearman and Pearson’s statistical tests were used to examine the relationship between variables. Multiple linear regressions were used to evaluate the predictability of injury through load-related parameters. The results showed that acute load, monotony, and strain were directly and moderately related to non-contact injuries. However, these parameters could not predict non-contact injuries in soccer players. It seems that paying attention to these parameters can help coaches to reduce soccer non-contact injury. However, more data is needed in this regard..