Studies in Sport Medicine

The effect of eight weeks of resistance training on motor function, fatigue and quality of life in women with multiple sclerosis

Document Type : Research Paper

Authors

Ali Shafizadeh 1
Nilofar Emamian 2
Masood Etemadifar 3

1 Shahre kord university

2 shahrekord University

3 Department of Neurosurgery, School of Medicine, Isfahan University of Medical Science, Isfahan,Ira

https://doi.org/10.22089/smj.2023.14704.1675
Abstract
The purpose of this study was to investigate the effect of eight weeks theraband Resistance training
on motor function, fatigue and quality of life in women with multiple sclerosis (MS). The population included women aged 20-50 years with MS with an expanded disability status scale between 1-2.5 and members of the Isfahan MS Association. Among the volunteer patients, 30 people with MS were selected by available sampling method and were divided into experimental and control groups (n=15). Subjects of both groups completed questionnaires quality of life and fatigue severity scale of MS patients before starting the training program and participated in the tests of timed up and go and 30-Second Chair stand. The experimental group performed theraband resistance training three times a week for 60 minutes for eight weeks, and the control group performed their daily activities during this time. After eight weeks, all of subjects were reevaluated with the previous tests. Data were analyzed by independent t test and analysis of covariance. The results showed that posttests of timed up and go (P = 0.001), 30-Second Chair stand (P = 0.001), fatigue severity (P = 0.001) and quality of life (P = 0.001) were significantly different between the experimental and control groups. the results of the experimental group showed that 30-Second Chair stand was 37.2%, timed up and go was 32.6%, quality of life increased by 22.9% and fatigue decreased by 22.1%. In general, theraband resistance training with special characteristics are recommended for the rehabilitation of MS patients.

Keywords

resistance training
multiple sclerosis
motor function
fatigue
quality of life

Main Subjects

  1. Kuhlmann T, Ludwin S, Prat A, Antel J, Brück W, Lassmann H. An updated histological classification system for multiple sclerosis lesions. Acta neuropathologica. 2017;133(1):13-24.
  2. Fleischer V, Radetz A, Ciolac D, Muthuraman M, Gonzalez-Escamilla G, Zipp F, et al. Graph theoretical framework of brain networks in multiple sclerosis: a review of concepts. Neuroscience. 2019;403:35-53.
  3. Chard DT, Alahmadi AA, Audoin B, Charalambous T, Enzinger C, Hulst HE, et al. Mind the gap: from neurons to networks to outcomes in multiple sclerosis. Nature Reviews Neurology. 2021;17(3):173-84.
  4. Ramagopalan SV, Sadovnick AD. Epidemiology of multiple sclerosis. Neurologic clinics. 2011;29(2):207-17.
  5. Gil-González I, Martín-Rodríguez A, Conrad R, Pérez-San-Gregorio M. Quality of life in adults with multiple sclerosis: a systematic review. BMJ open. 2020;10(11):e041249.
  6. Ramari C, Hvid LG, David ACd, Dalgas U. The importance of lower-extremity muscle strength for lower-limb functional capacity in multiple sclerosis: Systematic review. Annals of Physical and Rehabilitation Medicine. 2020;63(2):123-37.
  7. Kister I, Bacon TE, Chamot E, Salter AR, Cutter GR, Kalina JT, et al. Natural History of Multiple Sclerosis Symptoms. International Journal of MS Care. 2013;15(3):146-56.
  8. Marrie RA, Elliott L, Marriott J, Cossoy M, Blanchard J, Leung S, et al. Effect of comorbidity on mortality in multiple sclerosis. Neurology. 2015;85(3):240-7.
  9. Zifko UA. Management of fatigue in patients with multiple sclerosis. Drugs. 2004;64(12):1295-304.
  10. Bebo B, Cintina I, LaRocca N, Ritter L, Talente B, Hartung D, et al. The economic burden of multiple sclerosis in the United States: estimate of direct and indirect costs. Neurology. 2022;98(18):e1810-e7.
  11. Mahdizadeh A, Lokzadeh S, Riyahi A, Hosseini SA, Jalili N. The investigation of factors affecting the gait of the patients suffering from multiple sclerosis. Archives of Rehabilitation. 2019;20(1):64-73.
  12. Jørgensen M, Dalgas U, Wens I, Hvid LG. Muscle strength and power in persons with multiple sclerosis - A systematic review and meta-analysis. Journal of the neurological sciences. 2017;376:225-41.
  13. Charron S, McKay KA, Tremlett H. Physical activity and disability outcomes in multiple sclerosis: A systematic review (2011-2016). Multiple sclerosis and related disorders. 2018;20:169-77.
  14. Motl RW, Gosney JL. Effect of exercise training on quality of life in multiple sclerosis: a meta-analysis. Multiple sclerosis (Houndmills, Basingstoke, England). 2008;14(1):129-35.
  15. Sokolov AA, Grivaz P, Bove R. Cognitive Deficits in Multiple Sclerosis: Recent Advances in Treatment and Neurorehabilitation. Current treatment options in neurology. 2018;20(12):53.
  16. Weikert M, Suh Y, Lane A, Sandroff B, Dlugonski D, Fernhall B, et al. Accelerometry is associated with walking mobility, not physical activity, in persons with multiple sclerosis. Medical Engineering & Physics. 2012;34(5):590-7.
  17. White LJ, Dressendorfer RH. Exercise and multiple sclerosis. Sports medicine. 2004;34:1077-100.
  18. Bosnak-Guclu M, Guclu-Gunduz A, Nazliel B, Irkec C. Comparison of functional exercise capacity, pulmonary function and respirator y muscle strength in patients with multiple sclerosis with different disability levels and healthy controls. Journal of rehabilitation medicine. 2012;44:80–6.
  19. Kjølhede T, Vissing K, Langeskov-Christensen D, Stenager E, Petersen T, Dalgas U. Relationship between muscle strength parameters and functional capacity in persons with mild to moderate degree multiple sclerosis. Multiple sclerosis and related disorders. 2015;4(2):151-8.
  20. Yahia A, Ghroubi S, Mhiri C, Elleuch MH. Relationship between muscular strength, gait and postural parameters in multiple sclerosis. Annals of Physical and Rehabilitation Medicine. 2011;54(3):144-55.
  21. Callesen J, Dalgas U, Brincks J, Cattaneo D. How much does balance and muscle strength impact walking in persons with multiple sclerosis? - A cross-sectional study. Multiple sclerosis and related disorders. 2019;29:137-44.
  22. Bowser B, O'Rourke S, Brown CN, White L, Simpson KJ. Sit-to-stand biomechanics of individuals with multiple sclerosis. Clinical Biomechanics. 2015;30(8):788-94.
  23. White LJ, McCoy SC, Castellano V, Gutierrez G, Stevens JE, Walter GA, et al. Resistance training improves strength and functional capacity in persons with multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). 2004;10(6):668-74.
  24. Rad P, Zahmatkeshan N, Delaviz H, Enanat E. Comparing the Effectiveness of Isotonic and Isometric Exercises on Balance and Ability in Patients with Multiple Sclerosis. Journal of Clinical Care and Skills. 2021;2(1):9-13.
  25. Rommer PS, Eichstädt K, Ellenberger D, Flachenecker P, Friede T, Haas J, et al. Symptomatology and symptomatic treatment in multiple sclerosis: results from a nationwide MS registry. Multiple Sclerosis Journal. 2019;25(12):1641-52.
  26. Kratz AL, Murphy SL, Braley TJ. Ecological momentary assessment of pain, fatigue, depressive, and cognitive symptoms reveals significant daily variability in multiple sclerosis. Archives of physical medicine and rehabilitation. 2017;98(11):2142-50.
  27. Marchesi O, Vizzino C, Meani A, Conti L, Riccitelli GC, Preziosa P, et al. Fatigue in multiple sclerosis patients with different clinical phenotypes: a clinical and magnetic resonance imaging study. European Journal of Neurology. 2020;27(12):2549-60.
  28. Manjaly Z-M, Harrison NA, Critchley HD, Do CT, Stefanics G, Wenderoth N, et al. Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry. 2019;90(6):642-51.
  29. Fraser C, Morgante L, Hadjimichael O, Vollmer T. A prospective study of adherence to glatiramer acetate in individuals with multiple sclerosis. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. 2004;36(3):120-9.
  30. Atshzadh F, Shiri H, Sanii M. Effect of exercise on the ability to perform daily living activities of women with multiple sclerosis. J Rafsanjan Med Sci. 2004;2:30-40.
  31. Rietberg MB, Brooks D, Uitdehaag BM, Kwakkel G. Exercise therapy for multiple sclerosis. The Cochrane database of systematic reviews. 2005;2005(1):Cd003980.
  32. Motl RW, McAuley E, Snook EM, Gliottoni RC. Physical activity and quality of life in multiple sclerosis: intermediary roles of disability, fatigue, mood, pain, self-efficacy and social support. Psychology, health & medicine. 2009;14(1):111-24.
  33. Ramari C, Hvid LG, de David AC, Dalgas U. The importance of lower-extremity muscle strength for lower-limb functional capacity in multiple sclerosis: Systematic review. Annals of Physical and Rehabilitation Medicine. 2020;63(2):123-37.
  34. Dalgas U, Stenager E, Lund C, Rasmussen C, Petersen T, Sørensen H, et al. Neural drive increases following resistance training in patients with multiple sclerosis. Journal of neurology. 2013;260(7):1822-32.
  35. Kjølhede T, Vissing K, de Place L, Pedersen BG, Ringgaard S, Stenager E, et al. Neuromuscular adaptations to long-term progressive resistance training translates to improved functional capacity for people with multiple sclerosis and is maintained at follow-up. Multiple sclerosis (Houndmills, Basingstoke, England). 2015;21(5):599-611.
  36. Gaedtke A, Morat T. TRX Suspension Training: A New Functional Training Approach for Older Adults - Development, Training Control and Feasibility. International journal of exercise science. 2015;8(3):224-33.
  37. Giesser B, Beres-Jones J, Budovitch A, Herlihy E, Harkema S. Locomotor training using body weight support on a treadmill improves mobility in persons with multiple sclerosis: a pilot study. Multiple Sclerosis Journal. 2007;13(2):224-31.
  38. Ghigiarelli J, Nagle E, Gross F, Robertson R, Irrgang J, Myslinski T. The Effects of a 7-Week Heavy Elastic Band and Weight Chain Program on Upper-Body Strength and Upper-Body Power in a Sample of Division 1-AA Football Players. Journal of strength and conditioning research / National Strength & Conditioning Association. 2009;23:756-64.
  39. Keshtiaray A, Shojaedin SS, Hadadnezhad M. Resistance TheraBand Training of Special Core Stability Muscles on Movement Speed in Men with Multiple Sclerosis. Middle Eastern Journal of Disability Studies. 2020;10(37):1-6.
  40. Khorshid Sokhangu M, Ebrahimi Atri A, Hashemi Javaheri SAA, Sarvari F. The Effect of Resistance Exercise on Motor Control in Woman with Multiple Sclerosis. Qom University of Medical Sciences Journal. 2015;9(9):10-8.
  41. Aslankhani MA, Farsi A, Fathirezaie Z, Zamani Sani SH, Aghdasi MT. Validity and reliability of the timed up and go and the anterior functional reach tests in evaluating fall risk in the elderly. Iranian Journal of Ageing. 2015;10(1):16-25.
  42. Motaharinezhad F, Parvaneh S, Ghahari S. Fatigue in people with multiple sclerosis: Cause, evaluation and treatment. Journal of Paramedical Sciences & Rehabilitation. 2016;5(1):73-80.
  43. Mohammad K, Rimaz S, Dastoorpour M, Sadeghi M, Majdzadeh SR. Quality of Life and Related Factors among multiple sclerosis patients. Journal of School of Public Health and Institute of Public Health Research. 2014;11(4):1-14.
  44. Moradi B, Shojaedin SS, Hadadnezhad M. Effect of Eight Week Theraband Resistance Training on the Fatigue Severity, the Quality of Life, and the Muscular Strength of the Lower Extremity In Men with Multiple Sclerosis. 2016:146-58.
  45. Andreu-Caravaca L, Ramos-Campo DJ, Chung LH, Manonelles P, Abellán-Aynés O, Rubio-Arias JÁ. Effects of fast-velocity concentric resistance training in people with multiple sclerosis: A randomized controlled trial. Acta Neurologica Scandinavica. 2022;146(5):652-61.
  46. de Oliveira CEP, Moreira OC, Carrión-Yagual ZM, Medina-Pérez C, de Paz JA. Effects of classic progressive resistance training versus eccentric-enhanced resistance training in people with multiple sclerosis. Archives of physical medicine and rehabilitation. 2018;99(5):819-25.
  47. Moradi M, Sahraian MA, Aghsaie A, Kordi MR, Meysamie A, Abolhasani M, et al. Effects of Eight-week Resistance Training Program in Men With Multiple Sclerosis. 2015;6(2):e22838.
  48. Hosseini SS, Rajabi H, Sahraian MA, Moradi M, Mehri K, Abolhasani M. Effects of 8-Week Home-Based Yoga and Resistance Training on Muscle Strength, Functional Capacity and Balance in Patients with Multiple Sclerosis: A Randomized Controlled Study. 2018;9(3):e68807.
  49. Callesen J, Cattaneo D, Brincks J, Kjeldgaard Jørgensen M-L, Dalgas U. How do resistance training and balance and motor control training affect gait performance and fatigue impact in people with multiple sclerosis? A randomized controlled multi-center study. Multiple Sclerosis Journal. 2020;26(11):1420-32.
  50. DeBolt LS, McCubbin JA. The effects of home-based resistance exercise on balance, power, and mobility in adults with multiple sclerosis. Archives of physical medicine and rehabilitation. 2004;85(2):290-7.
  51. Pariser G, Madras D, Weiss E. Outcomes of an aquatic exercise program including aerobic capacity, lactate threshold, and fatigue in two individuals with multiple sclerosis. Journal of Neurologic Physical Therapy. 2006;30(2):82-90.
  52. Amiri N, Moazzami M, Yaghoubi A. Effect of 8-Week Resistance Training on Balance, Fatigue, and Muscle Strength in Women with Multiple Sclerosis. Journal of North Khorasan University of Medical Sciences. 2020;12(3):62-8.
  53. Heine M, van de Port I, Rietberg MB, van Wegen EE, Kwakkel G. Exercise therapy for fatigue in multiple sclerosis. Cochrane database of systematic reviews. 2015(9).
  54. Kierkegaard M, Lundberg IE, Olsson T, Johansson S, Ygberg S, Opava C, et al. High-intensity resistance training in multiple sclerosis—An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition. Journal of the neurological sciences. 2016;362:251-7.
  55. Englund S, Piehl F, Kierkegaard M. High-intensity resistance training in people with multiple sclerosis experiencing fatigue: A randomised controlled trial. Multiple sclerosis and related disorders. 2022;68:104106.
  56. Karpatkin HI, Cohen ET, Klein S, Park D, Wright C, M. Z. The Effect of Maximal Strength Training on Strength, Walking, and Balance in People with Multiple Sclerosis: A Pilot Study. Mult Scler Int. 2016;2016:5235971.
  57. Khademosharie M, Tadibi V, Behpor N, Hamedinia M. Effect of 12-week endurance-resistance training on motor and muscular function, degree of disability, fatigue, and quality of life in Multiple Sclerosis patients. Iranian Journal of Epidemiology. 2018;14(1):95-104.
  58. Correale L, Buzzachera CF, Liberali G, Codrons E, Mallucci G, Vandoni M, et al. Effects of combined endurance and resistance training in women with multiple sclerosis: a randomized controlled study. Frontiers in Neurology. 2021;12:698460.
  59. Moghadasi A, Ghasemi GA, Abbasi M. Effects of total body resistance exercise on sexual function and quality of life in female with multiple sclerosis. 2021;23(5):627-635.
  60. Gil-González I, Martín-Rodríguez A, Conrad R, et al. Quality of life in adults with multiple sclerosis: a systematic review. BMJ Open .2020;10:e041249
  61. Mohamadzadeh M, Rahnama N, Shahrbanian S, Moghadas-Tabrizi Y. Comparison of the Effect of Eight Weeks Resistance, Balance, and Combined Training Program on Balance, Gait, and Quality of Life in Patients with Multiple Sclerosis: A Pretest-Posttest Intervention. Journal of Research in Rehabilitation Sciences. 2017;12(6):332-40.
  62. Romberg A, Virtanen A, Ruutiainen J. Long–term exercise improves functional impairment but not quality of life in multiple sclerosis. Journal of neurology. 2005;252:839-45.
  63. Rice CL, Vollmer TL, Bigland-Ritchie B. Neuromuscular responses of patients with multiple sclerosis. Muscle Nerve. 1992;15(10):1123-32.
  64. van der Kamp W, Maertens de Noordhout A, Thompson PD, Rothwell JC, Day BL, CD M. Correlation of phasic muscle strength and corticomotoneuron conduction time in multiple sclerosis. Ann Neurol. 1991;29(1):6-12.
  65. Gutierrez GM, Chow JW, Tillman MD, McCoy SC, Castellano V, White LJ. Resistance training improves gait kinematics in persons with multiple sclerosis. Archives of physical medicine and rehabilitation. 2005;86(9):1824-9.
  66. Wens I, Dalgas U, Vandenabeele F, Krekels M, Grevendonk L, Eijnde BO. Multiple sclerosis affects skeletal muscle characteristics. PloS one. 2014;9(9):e108158.

 

Studies in Sport Medicine
Volume 15, Issue 38
December 2024
Pages 47-64

  • Receive Date 25 April 2023
  • Revise Date 28 July 2023
  • Accept Date 27 August 2023

Home

Publication Ethics

Submit Manuscript

news

Journal Metrics

Contact Us