The purpose of this study was to investigate the effect of eight weeks theraband Resistance training
on motor function, fatigue and quality of life in women with multiple sclerosis (MS). The population included women aged 20-50 years with MS with an expanded disability status scale between 1-2.5 and members of the Isfahan MS Association. Among the volunteer patients, 30 people with MS were selected by available sampling method and were divided into experimental and control groups (n=15). Subjects of both groups completed questionnaires quality of life and fatigue severity scale of MS patients before starting the training program and participated in the tests of timed up and go and 30-Second Chair stand. The experimental group performed theraband resistance training three times a week for 60 minutes for eight weeks, and the control group performed their daily activities during this time. After eight weeks, all of subjects were reevaluated with the previous tests. Data were analyzed by independent t test and analysis of covariance. The results showed that posttests of timed up and go (P = 0.001), 30-Second Chair stand (P = 0.001), fatigue severity (P = 0.001) and quality of life (P = 0.001) were significantly different between the experimental and control groups. the results of the experimental group showed that 30-Second Chair stand was 37.2%, timed up and go was 32.6%, quality of life increased by 22.9% and fatigue decreased by 22.1%. In general, theraband resistance training with special characteristics are recommended for the rehabilitation of MS patients.