نوع مقاله : مقاله پژوهشی
نویسندگان
1 کارشناس ارشد آسیب شناسی ورزشی و حرکات اصلاحی، دانشگاه بین المللی امام رضا (ع)، مشهد
2 استادیار گروه علوم ورزشی، موسسه آموزش عالی خاوران، مشهد، ایران
3 استادیار پژوهشگاه تربیت‌بدنی، تهران، ایران
4 گروه علوم ورزشی. دانشگاه بین المللی امام رضا علیه السلام.
چکیده
همراه با تغییرات هورمونی طی فرآیند یائسگی، نشان داده شده است که هورمون ریلکیسن در ارتباط با هورمون استروژن میتواند تغییراتی را در عملکرد سیستمهای بدنی دارا باشد. لذا، هدف از تحقیق حاضر ارتباط سنجی بین سطوح ریلکسین و آسیب‌های عضلانی-اسکلتی در زنان تمرین کرده یائسه و جوان بود. این مطالعه از نوع تحقیقات تحلیلی - توصیفی بود که به صورت گذشته نگر انجام پذیرفت. این پژوهش شامل دو گروه متشکل از زنان تمرین کرده یائسه (تعداد 13 نفر زن یائسه با دامنه سنی60 – 45 سال) و جوان (تعداد 8 نفر زن جوان با دامنه سنی 30 – 18 سال) بود که پس از فراخوان عمومی طبق معیارهای ورود و خروج تحقیق انتخاب شدند. سپس، اندازهگیریهای مربوط به سطح و سابقه فعالیت ورزشی، یائسگی، آسیبها و اختلالات عضلانی-اسکلتی و نمونه گیری خونی انجام پذیرفت. پس از جمعآوری دادهها، از نرم افزاری آماری Stata نسخه 12 جهت تجزیه و تحلیل دادهها سطح معناداری 05/0 p< استفاده شد. نتایج بیانگر آن بود که سطح ریلکسین زنان تمرین کرده یائسه نسبت به زنان جوان به طور معناداری پایینتر بود(46/3= 19t و 003/0=P). همچنین، نتایج نشان داد که ارتباط بین ریلکسین و آسیب‌های عضلانی اسکلتی به لحاظ آماری معنادار نبود (05/0<p). مطالعه حاضر نشان داد که سطوح ریلکیسن زنان یائسه تمرین کرده نسبت به زنان جوان تمرین کرده پایینتر است و احتمالا تغییرات سن، بروز یائسگی و تغییرات هورمونی وابسته به آن و نه لزوما سابقه ورزشی عامل کاهش ریلکسین است.
کلیدواژه‌ها
عنوان مقاله [English]
Title: The relationship between relaxin levels and musculoskeletal injuries in young and menopausal trained women
نویسندگان [English]
- Manije Shibak 1
- Sadegh Abbasian 2
- Hamed Abbasi 3
- amin azimkhani 4
1 Master of Science, Sports Sciences group, Imam Reza International University, Mashhad, Iran
2 Assistant professor of Sports Sciences group, Khavaran Institute of Higher Education, Mashhad, Iran,
3 Sport Sciences Research Institute, Tehran, Iran,
4 Department of Sports Science. Imam Reza International University.
چکیده [English]
It has been illustrated that relaxin hormone in association with estrogen may induce changes in functional body systems following menopausal stage. Therefore, the aim of this study was to determine the relationship between relaxin levels and musculoskeletal injuries in young and menopausal trained women. The present study used descriptive analytical method via retrospective manner. This study involved two determined groups included menopausal trained women (n=13, aged 45-60 years) and young trained women (n=8, aged 18-30 years) that were chose following public recall based on inclusion and exclusion criteria. Then, study measurements regarding blood samples, training level, training history, menopause stage, injuries and musculoskeletal impairments were done. Finally, Stata v12 statistical software was used for data analysis at (p < 0.05). Our results illustrated that relaxin level in menopausal trained women significantly was lower than young trained women (p = 0.003, t19=3.46). Also, our results presented that there was no statistically significant relationship between relaxin and musculoskeletal injuries (p>0.05). Regarding postmenopausal hormone changes, it has been shown that relaxin hormone in relation with estrogen hormone can induce alterations in functions body systems.
کلیدواژه‌ها [English]
- Estrogen
- Menopause
- Relaxin
- Training history
- Grant MD, Marbella A, Wang AT, Pines E, Hoag J, Bonnell C, et al. Menopausal Symptoms: Comparative Effectiveness of Therapies [Internet]. 2015.
- Soules MR, Sherman S, Parrott E, Rebar R, Santoro N, Utian W, et al. Executive summary: stages of reproductive aging workshop (STRAW). Climacteric. 2001;4(4):267-72.
- Santoro N, Epperson CN, Mathews SB. Menopausal symptoms and their management. Endocrinology and Metabolism Clinics. 2015;44(3):497-515.
- Society NAM. Menopause practice: a clinician's guide: North American Menopause Society; 2007.
- Spritzer PM, Wender MCO. Hormone therapy in menopause: when not to use. Arquivos Brasileiros de Endocrinologia & Metabologia. 2007;51(7):1058-63.
- Peacock K, Ketvertis KM. History and Physical. 2020.
- Hisaw FL. Experimental relaxation of the pubic ligament of the guinea pig. Proceedings of the Society for Experimental Biology and Medicine. 1926;23(8):661-3.
- Conrad KP, Baker VL. Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductive technologies. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2013;304(2):R69-R72.
- Dehghan F, Haerian B, Muniandy S, Yusof A, Dragoo J, Salleh N. The effect of relaxin on the musculoskeletal system. Scandinavian journal of medicine & science in sports. 2014;24(4):e220-e9.
- Dragoo JL, Castillo TN, Braun HJ, Ridley BA, Kennedy AC, Golish SR. Prospective correlation between serum relaxin concentration and anterior cruciate ligament tears among elite collegiate female athletes. The American journal of sports medicine. 2011;39(10):2175-80.
- Pearson S, Burgess K, Onambélé G. Serum relaxin levels affect the in vivo properties of some but not all tendons in normally menstruating young women. Experimental physiology. 2011;96(7):681-8.
- Wood ML, Luthin WN, Lester GE, Dahners LE. Tendon creep is potentiated by NKISK and relaxin which produce collagen fiber sliding. The Iowa orthopaedic journal. 2003;23:75.
- Heringlake M, Kox T, Poeling J, Klaus S, Hanke T, Franz N, et al. The effects of physical exercise on plasma levels of relaxin, NTproANP, and NTproBNP in patients with ischemic heart disease. European journal of medical research. 2009;14(3):106-12.
- Krüger S, Graf J, Merx MW, Stickel T, Kunz D, Hanrath P, et al. Relaxin kinetics during dynamic exercise in patients with chronic heart failure. European journal of internal medicine. 2004;15(1):54-6.
- Schoenfeld J, Haller B, Weichenberger M, Lorenz ES, Grabs V, Halle M, et al. Prolonged and strenuous exercise does not influence serum relaxin levels in healthy male athletes. European journal of preventive cardiology. 2020;27(19):2351-3.
- Sonaglia F, Milia P, Caserio M, Bigazzi B, Bigazzi B, Ricotta S, et al. Efficacy and safety of oral porcine relaxin (pRLX) in adjunct to physical exercise in the treatment of peripheral arterial disease (PAD). Italian Journal of Anatomy and Embryology. 2013;118(1):84.
- Rezvani MH. The Effects of Eight Weeks Resistance Training and Low Caloric Diet on Body Composition, Serum's Relaxin and Lipid Profiles of Postmenopausal Women. Journal of Exercise Physiology and Physical Activity. 2017;10(2):99-106.
- Mir A, Azarbayjani MA, Matin Homaei H, Fanaei H. The effect of different intensity of resistsnce and aerobic exercises on serum relaxin levels in ovariectomized rats. Journal of Practical Studies of Biosciences in Sport. 2019;7(14):45-55.
- Negishi S, Li Y, Usas A, Fu FH, Huard J. The effect of relaxin treatment on skeletal muscle injuries. The American journal of sports medicine. 2005;33(12):1816-24.
- Kotz K, Alexander JL, Dennerstein L. Estrogen and androgen hormone therapy and well-being in surgically postmenopausal women. Journal of Women's Health. 2006;15(8):898-908.
- Sternfeld B, Bhat AK, Wang H, Sharp T, CHARLES P QUESENBERRY J. Menopause, physical activity, and body composition/fat distribution in midlife women. Medicine & Science in Sports & Exercise. 2005;37(7):1195-202.
- Ayati S, Kadkhodayan S, Vahid Rudsari F, Shakeri M. Investigating the relationship between underlying and environmental factors on clinical signs of menopause. Babol University of Medical Sciences. 2008;10(1):40-5.
- Figueroa A, Going SB, Milliken LA, Blew RM, Sharp S, Teixeira PJ, et al. Effects of exercise training and hormone replacement therapy on lean and fat mass in postmenopausal women. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2003;58(3):M266-M70.
- McKinlay S, McKinlay T, Avis N. The Massachusetts Women’s Health Study: a longitudinal study of health of mid aged women and the epidemiology of menopause. Psychol Women. 1989;16:1-4.
- Sternfeld B, Ainsworth BE, Quesenberry Jr C. Physical activity patterns in a diverse population of women. Preventive medicine. 1999;28(3):313-23.
- Namnik N, Negahban H, Salehi R, Shafizadeh R, Tabib MS. Validity and reliability of Persian version of the Specific Nordic questionnaire in Iranian industrial workers. Work. 2016;54(1):35-41.
- Greene G. Constructing a standard climacteric scale. Maturitas. 1998;29(1):25-31.
- Smith KW, Avis NE, Assmann SF. Distinguishing between quality of life and health status in quality of life research: a meta-analysis. Quality of life research. 1999;8(5):447-59.
- Khodadadi H, Rajabi H, Attarzadeh SR, Reza S, Abbasian S. The Effect of High Intensity Interval Training (HIIT) and Pilates on Levels of Irisin and Insulin Resistance in Overweight Women. Iranian Journal of Endocrinology and Metabolism. 2014;16(3):190-6.
- Ferlin A, Pepe A, Facciolli A, Gianesello L, Foresta C. Relaxin stimulates osteoclast differentiation and activation. Bone. 2010;46(2):504-13.
- Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, et al. New roles for INSL3 in adults. Annals of the New York Academy of Sciences. 2009;1160(1):
215-8. - Fenton A, Panay N. Estrogen, menopause and joints. Taylor & Francis; 2016.
- Ren Y, Tan B, Yan P, You Y, Wu Y, Wang Y. Association between polymorphisms in the estrogen receptor alpha gene and osteoarthritis susceptibility: a meta-analysis. BMC musculoskeletal disorders. 2015;16(1):1-10.
- Martín-Millán M, Castañeda S. Estrogens, osteoarthritis and inflammation. Joint Bone Spine. 2013;80(4):368-73.
- Bathgate R, Halls ML, van der Westhuizen ET, Callander G, Kocan M, Summers RJ. Relaxin family peptides and their receptors. Physiological reviews. 2013;93(1):405-80.
- Agoulnik AI. Relaxin and related peptides in male reproduction. Relaxin and Related Peptides. 2007:49-64.
- Kong RC, Shilling PJ, Lobb DK, Gooley PR, Bathgate RA. Membrane receptors: structure and function of the relaxin family peptide receptors. Molecular and cellular endocrinology. 2010;320(1-2):1-15.
- Figueiredo KA, Mui AL, Nelson CC, Cox ME. Relaxin stimulates leukocyte adhesion and migration through a relaxin receptor LGR7-dependent mechanism. Journal of Biological Chemistry. 2006;281(6):3030-9.
- Qin X, Garibay-Tupas J, Chua PK, Cachola L, Bryant-Greenwood GD. An autocrine/paracrine role of human decidual relaxin. I. Interstitial collagenase (matrix metalloproteinase-1) and tissue plasminogen activator. Biology of reproduction. 1997;56(4):800-11.
- Wiqvist I, Norström A, O'Byrne E, Wiqvist N. Regulatory influence of relaxin on human cervical and uterine connective tissue. European Journal of Endocrinology. 1984;106(1):127-32.
- Koay ES, Too CK, Greenwood F, Bryant-Greenwood GD. Relaxin stimulates collagenase and plasminogen activator secretion by dispersed human amnion and chorion cells in vitro. The Journal of Clinical Endocrinology & Metabolism. 1983;56(6):1332-4.
- Bitto A, Irrera N, Minutoli L, Calò M, Lo Cascio P, Caccia P, et al. Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice. Clinical science. 2013;125(12):575-85.
- Bonaventure J, de La Tour B, Tsagris L, Eddie L, Tregear G, Corvol M. Effect of relaxin on the phenotype of collagens synthesized by cultured rabbit chondrocytes. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1988;972(2):
209-20. - Naqvi T, Duong TT, Hashem G, Shiga M, Zhang Q, Kapila S. Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants. Arthritis Res Ther. 2004;7(1):1-11.
- Lekgabe ED, Royce SG, Hewitson TD, Tang ML, Zhao C, Moore XL, et al. The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs. Endocrinology. 2006;147(12):5575-83.
- Agarwal S, Alzahrani FA, Ahmed A. Hormone Replacement Therapy: Would it be Possible to Replicate a Functional Ovary? International journal of molecular sciences. 2018;19(10):3160.
- Bani D. Relaxin as a natural agent for vascular health. Vascular Health and Risk Management. 2008;4(3):515.
- Multanen J, Heinonen A, Häkkinen A, Kautiainen H, Kujala U, Lammentausta E, et al. Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis. Journal of musculoskeletal & neuronal interactions. 2015;15(1):69.
- Szoeke CE, Cicuttini FM, Guthrie JR, Dennerstein L. The relationship of reports of aches and joint pains to the menopausal transition: a longitudinal study. Climacteric. 2008;11(1):55-62.
- Gao H, Lin S, Wei Y, Chen Y, Wu Z. The effect of age and menopausal status on musculoskeletal symptoms in Chinese women aged 35–64 years. Climacteric. 2013;16(6):639-45.
- Khadilkar SS. Musculoskeletal disorders and menopause. Springer; 2019.
- Watt FE. Musculoskeletal pain and menopause. Post reproductive health. 2018;24(1):34-43.
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